The Cell in Development and Inheritance.
Written by Edmund Beecher Wilson in 1911. He was the first person to recognize and understand that tumor cells have abnormal chromosome divisions by looking at cells under a light microscope. He's really the founder of cellular biology, and we still use his concepts and basic findings ALL the time today. How cool is that? I think this book would be a nice addition to my small but loved collection of old books, including a recent find at the Mt. Zion Medical Library earlier this spring (a copy of William James' seminal work in psychology, "Principes of Psychology").
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